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List:       r-sig-mixed-models
Subject:    Re: [R-sig-ME] Performing a single animal model that estimates additive genetic variation for many p
From:       Pierre de Villemereuil <pierre.de.villemereuil () mailoo ! org>
Date:       2015-06-18 13:33:32
Message-ID: 2591856.akHJoJOsm9 () flyosfixe
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Dear all,

A kind of "multi-population" animal model framework which accounts for inter-
population, as well as for intra-population genetic structure has been developed 
by Ovaskainen /et al./:
Ovaskainen, O., Karhunen, M., Zheng, C., Arias, J. M. C. & Merilä, J. A new method to 
uncover signatures of divergent and stabilizing selection in quantitative traits. 
/Genetics/ *189,* 621–632 (2011). 

Instead of assuming a homogeneous Va across population, but maybe having a 
population×additive genetic interaction (i.e. a population-specific Va component) 
would solve this issue?

Regards,Pierre

Le jeudi 18 juin 2015, 10:55:07 David Duffy a écrit :
> On Thu, 18 Jun 2015, Jackie Wood wrote:
> > I'm working on a manuscript which investigates the relationship of various
> > metrics of adaptive potential (additive genetic variation (VA),
> > heritability (h2), and mean-scaled evolvability (IA)) with population size
> > in a common garden experiment using a large number of wild, isolated
> > populations of a vertebrate fish. One comment/request we received on the
> > manuscript was whether we could fit a single animal model that includes
> > all
> > of our populations. That is, in addition to the standard terms to estimate
> > VA, whether we could also include population size and interactions with
> > population size such that we could examine whether VA (or h2 or IA) varies
> > among populations, and the magnitude of the interaction between population
> > and additive (and potentially maternal) effects.
> 
> Yes ;) It is essentially a GxE term. Probably MCMCglmm would be easiest.
> 
> | David Duffy (MBBS PhD)
> | email: David.Duffy@qimrberghofer.edu.au  ph: INT+61+7+3362-0217 fax: -0101
> | Genetic Epidemiology, QIMR Berghofer Institute of Medical Research
> | 300 Herston Rd, Brisbane, Queensland 4006, Australia  GPG 4D0B994A
> 
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