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http://bugs.kde.org/show_bug.cgi?id=111855         
           Summary: default suppression file is read 1 byte at a time
           Product: valgrind
           Version: unspecified
          Platform: Compiled Sources
        OS/Version: Linux
            Status: UNCONFIRMED
          Severity: normal
          Priority: NOR
         Component: memcheck
        AssignedTo: jseward acm org
        ReportedBy: jreiser bitwagon com


Version:           valgrind-3.0.1 (using KDE Devel)
Installed from:    Compiled sources
Compiler:          gcc (GCC) 4.0.1 20050727 (Red Hat 4.0.1-5) 
OS:                Linux

Memcheck reads the default suppression file using one system call read() for each byte in the file.  Ordinarily this is the slowest method.  Using a larger buffer might reduce startup time of memcheck by enough to notice (a second or two).

Evidence: run "strace -o strace.out valgrind301 date"
then examine strace.out:
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open("/usr/local/valgrind301/lib/valgrind/default.supp", O_RDONLY) = 3
read(3, "#", 1)                         = 1
read(3, " ", 1)                         = 1
read(3, "T", 1)                         = 1
read(3, "h", 1)                         = 1
read(3, "i", 1)                         = 1
read(3, "s", 1)                         = 1
read(3, " ", 1)                         = 1
read(3, "i", 1)                         = 1
read(3, "s", 1)                         = 1
read(3, " ", 1)                         = 1
read(3, "a", 1)                         = 1
read(3, " ", 1)                         = 1
read(3, "g", 1)                         = 1
read(3, "e", 1)                         = 1
read(3, "n", 1)                         = 1
read(3, "e", 1)                         = 1
read(3, "r", 1)                         = 1
read(3, "a", 1)                         = 1
read(3, "t", 1)                         = 1
read(3, "e", 1)                         = 1
read(3, "d", 1)                         = 1
read(3, " ", 1)                         = 1
read(3, "f", 1)                         = 1
read(3, "i", 1)                         = 1
  ...
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